The latest Diablo 4 cinematic trailer from Blizzard has Inarius in a battle against Lilith and armies on both D2R Items their backs. While the film doesn't mention Tyrael's direct involvement, his involvement in the creation of Horadrim and influence with the various Paladins of Sanctuary indicates that he's involved. Light and dark battles on the battlefield, and the now-mortal Tyrael is somewhere in the middle.
It is likely his presence will be perceived through these intermediaries unless events cause him to act. Tyrael is still feeling the repercussions of destroying his Worldstone at the end of Diablo 2. The mystical artifact shielded Sanctuary from Heaven and Hell, and he now protects the region in its place. Tyrael is unlikely to lead any further steps into Hell or take his fight any further beyond what is known as the Pandemonium Fortress, where he may provide guidance like Deckard Cain to those who are willing to listen.
Five Diablo playable classes are currently being announced each of which variations on the options offered in previous games. With each of the games that has been released so far has introduced something new Perhaps Tyrael will be an important player in the fight that balances the sides, offering players the opportunity to take on angelic or demon-like powers in exchange for obligations to Sanctuary. This type of mechanic could be a natural progression from the multi-tree expansion that was previously in the game.
It seems unlikely that Blizzard will make Angels as well as Demons into classes, as the series focuses on characters trapped between their ways. As the one who is who is caught between Heaven and Hell Tyrael has an unimaginable position in all of Diablo story. It is likely that he will be acting as a balancer throughout the story, and maybe even a voice of reason, rather than picking sides as previously. When he's forced into taking positions, Tyrael understands what is important to mortals d2r items for sale and that's the reason he'll participate in the events of Diablo 4.